Galatians 5:17 - For the desires of the flesh are against the Spirit, and the desires of the Spirit are against the flesh, for these are opposed to each other, to keep you from doing the things you want to do.
Satisfaction is noun describing the pleased feeling that follows something that you did, and/or the act of providing what is needed.
The Bible is wholly true and always accurate. In light of this fact I have concluded that mankind will never be satisfied. A semblence of satisfaction likely exists in the utterly depraved or the absolutely Christ-like. For the rest of us when the flesh is pleased we are tormented by the Spirit of God and/or our conscience. These two will ever remind me of my follies and this will grieve me and ushers out what pleased feeling I have in response to whatever my actions are. On the good days if my spirit is pleased then my flesh in response is offended and makes it a point to remind me, it is so bold as to say, "That is enough Godliness for today, you should not do too much. You are not a fanatic, besides if you are too good they will all see when you mess things up." The pleasure of the flesh grates against the spirit and the happiness of the spirit grieves the flesh so I am never satisfied, I am never pleased by my actions nor can I provide what is needed.
Now for the utterly depraved I would posit that they have so scarred their conscience and are so resistant to the Spirit of God what for me is a contest is for them a declaration of war by a worm. The same applies for the absolutely righteous, they have so ignored their flesh it is emaciated and so starved it cannot squeak in protest. Is there a threshold then? Because however righteous I have become I have still been able to hear the displeasure of my flesh, and my wallowing in vice however far I go I feel my conscience scratching at my eyeballs..."I can't get no satisfaction" and I never will.